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Machado Garry faces off against second-ranked Carlos Prates and third-ranked Michael Morales to secure a title shot.
Brazil’s Prates has knocked out his last three opponents, although Machado lost to Garry in April last year, while Ecuador’s Morales has won all 19 of his fights.
In 2024, Machado lost a number one contender fight against Gary Shavkat Rakhmanov but the Kazakh fighter has not fought since battling injury.
In February, he was removed from the UFC’s welterweight rankings, which promoted Machado Gary.
The last fighter from Ireland to compete for a belt in a major MMA promotion was Carl Moore when he lost a Bellator light-heavyweight title fight to Corey Anderson in 2024.
In the co-main event in Philadelphia, American-Brazilian Mackenzie Dern will defend her strawweight title for the first time against Canada’s Gillian Robertson.
Dern, 33, defeated Virna Zandiroba for the belt in October for her third straight victory, while Robertson, 31, entered the fight on a five-fight winning streak.